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Open Access

Peer-reviewed

Research Article

Designing and Analyzing Clinical Trials with Composite Outcomes: Consideration of Possible Treatment Differences between the Individual Outcomes

  • Janice Pogue ,

    Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    janice.pogue@phri.ca

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    ⨯
  • P. J. Devereaux ,

    Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    ⨯
  • Lehana Thabane ,

    Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    Affiliation Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

    ⨯
  • Salim Yusuf

    Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    ⨯

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