Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

Quan-Guang Zhang; Melissa D. Laird; Dong Han; Khoi Nguyen; Erin Scott; Yan Dong; Krishnan M. Dhandapani; Darrell W. Brann

doi:10.1371/journal.pone.0034504

Loading metrics

Open Access

Peer-reviewed

Research Article

Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

Quan-Guang Zhang ,

Contributed equally to this work with: Quan-Guang Zhang, Melissa D. Laird

Affiliation Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Melissa D. Laird ,

Contributed equally to this work with: Quan-Guang Zhang, Melissa D. Laird

Affiliation Department of Neurosurgery, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Dong Han,

Affiliation Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Khoi Nguyen,

Affiliation Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Erin Scott,

Affiliation Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Yan Dong,

Affiliation Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Krishnan M. Dhandapani,

Affiliation Department of Neurosurgery, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Darrell W. Brann

* E-mail: dbrann@georgiahealth.edu

Affiliation Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯

Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

Quan-Guang Zhang,
Melissa D. Laird,
Dong Han,
Khoi Nguyen,
Erin Scott,
Yan Dong,
Krishnan M. Dhandapani,
Darrell W. Brann

x

Published: April 2, 2012
https://doi.org/10.1371/journal.pone.0034504

Viewed

Cited

Saved

Discussed

Powered by Altmetric

Questions or concerns about usage data? Please let us know.

Print

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Traumatic brain injury
Is the Subject Area "Traumatic brain injury" applicable to this article?

Thanks for your feedback.
Hippocampus
Is the Subject Area "Hippocampus" applicable to this article?

Thanks for your feedback.
Cerebral cortex
Is the Subject Area "Cerebral cortex" applicable to this article?

Thanks for your feedback.
Brain damage
Is the Subject Area "Brain damage" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Oxidative damage
Is the Subject Area "Oxidative damage" applicable to this article?

Thanks for your feedback.
Immunostaining
Is the Subject Area "Immunostaining" applicable to this article?

Thanks for your feedback.
Neuronal death
Is the Subject Area "Neuronal death" applicable to this article?

Thanks for your feedback.