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Open Access

Peer-reviewed

Research Article

Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses

  • Joseph T. Bruder ,

    jbruder@genvec.com

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • Elena Semenova,

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • Ping Chen,

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • Keith Limbach,

    Affiliation US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America

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  • Noelle B. Patterson,

    Affiliation US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America

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  • Maureen E. Stefaniak,

    Affiliation US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America

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  • Svetlana Konovalova,

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • Charlie Thomas,

    Current address: University of California San Diego, La Jolla, California, United States of America

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • Melissa Hamilton,

    Current address: MedImmune, Inc., Gaithersburg, Maryland, United States of America

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • C. Richter King,

    Current address: International Aids Vaccine Initiative, New York, New York, United States of America

    Affiliation Research, GenVec, Inc., Gaithersburg, Maryland, United States of America

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  • Thomas L. Richie,

    Affiliation US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America

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  • Denise L. Doolan

    Affiliations US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Queensland Institute of Medical Research, Brisbane, Australia

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