Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B12

Jill A. McKay; Alexandra Groom; Catherine Potter; Lisa J. Coneyworth; Dianne Ford; John C. Mathers; Caroline L. Relton

doi:10.1371/journal.pone.0033290

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Peer-reviewed

Research Article

Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B₁₂

Jill A. McKay ,

* E-mail: jill.mckay@ncl.ac.uk

Affiliations Institute for Ageing and Health, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Institute of Genetic Medicine, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Institute for Cell and Molecular Biology, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
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Alexandra Groom,

Affiliation Institute of Genetic Medicine, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
⨯
Catherine Potter,

Affiliation Institute of Genetic Medicine, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
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Lisa J. Coneyworth,

Affiliation Institute for Cell and Molecular Biology, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
⨯
Dianne Ford,

Affiliation Institute for Cell and Molecular Biology, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
⨯
John C. Mathers,

Affiliation Institute for Ageing and Health, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
⨯
Caroline L. Relton

Affiliation Institute of Genetic Medicine, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
⨯

Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B₁₂

Jill A. McKay,
Alexandra Groom,
Catherine Potter,
Lisa J. Coneyworth,
Dianne Ford,
John C. Mathers,
Caroline L. Relton

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Published: March 30, 2012
https://doi.org/10.1371/journal.pone.0033290

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DNA methylation
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Infants
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Methylation
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Genetic loci
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Cobalamins
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DNA metabolism
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