A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels

• Philippe Froguel ,

  Contributed equally to this work with: Philippe Froguel, Ndeye Coumba Ndiaye

  * E-mail: p.froguel@imperial.ac.uk (PF); Sophie.Visvikis-Siest@inserm.fr (SVS)

  Affiliations Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France, Genomic Medicine, Imperial College London, Hammersmith Hospital, London, England

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• Ndeye Coumba Ndiaye ,

  Contributed equally to this work with: Philippe Froguel, Ndeye Coumba Ndiaye

  Affiliation EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France

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• Amélie Bonnefond,

  Affiliations Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France, EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France

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• Nabila Bouatia-Naji,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France

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• Aurélie Dechaume,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France

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• Gérard Siest,

  Affiliation EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France

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• Bernard Herbeth,

  Affiliation EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France

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• Mario Falchi,

  Affiliation Genomic Medicine, Imperial College London, Hammersmith Hospital, London, England

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• Leonardo Bottolo,

  Affiliation Genomic Medicine, Imperial College London, Hammersmith Hospital, London, England

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• Rosa-Maria Guéant-Rodriguez,

  Affiliation Institut National de la Santé et de la Recherche Médicale (INSERM) U954, Faculté de Médecine, Nancy-Université, Nancy, France

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• Cécile Lecoeur,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France

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• Michel R. Langlois,

  Affiliations Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium, Department of Cardiovascular Diseases, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium

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• Yann Labrune,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France

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• Aimo Ruokonen,

  Affiliation Institute of Clinical Medicine/Biochemistry, University of Oulu, Oulu, Finland

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• Said El Shamieh,

  Affiliation EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France

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• Maria G. Stathopoulou,

  Affiliation EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France

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• Anita Morandi,

  Affiliations Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France, Regional Centre for Juvenile Diabetes, Obesity and Clinical Nutrition, Verona, Italy

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• Claudio Maffeis,

  Affiliation Regional Centre for Juvenile Diabetes, Obesity and Clinical Nutrition, Verona, Italy

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• David Meyre,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France

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• Joris R. Delanghe,

  Affiliation Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium

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• Peter Jacobson,

  Affiliation Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Lars Sjöström,

  Affiliation Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Lena M. S. Carlsson,

  Affiliation Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Andrew Walley,

  Affiliation Genomic Medicine, Imperial College London, Hammersmith Hospital, London, England

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• Paul Elliott,

  Affiliation Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Marjo-Riita Jarvelin,

  Affiliations Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, England, Institute of Health Sciences, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland

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• George V. Dedoussis,

  Affiliations EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France, Department of Nutrition–Dietetics, Harokopio University, Athens, Greece

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•  [ ... ],
• Sophie Visvikis-Siest

  * E-mail: p.froguel@imperial.ac.uk (PF); Sophie.Visvikis-Siest@inserm.fr (SVS)

  Affiliations EA4373–‘Cardio-vascular Genetics’ Research Unit, Université de Lorraine, Nancy, France, Department of Internal Medicine and Geriatrics, ‘Centre Hospitalier Universitaire de Nancy’, Nancy, France

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