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Research Article

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

  • Li Shen,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Michael Ciesielski,

    Affiliation: Department of Neuro-Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Swathi Ramakrishnan,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Kiersten M. Miles,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Leigh Ellis,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Paula Sotomayor,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Protul Shrikant,

    Affiliation: Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Robert Fenstermaker,

    Affiliation: Department of Neuro-Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Roberto Pili mail

    Roberto.Pili@RoswellPark.org

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

    X
  • Published: January 27, 2012
  • DOI: 10.1371/journal.pone.0030815

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