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Open Access

Peer-reviewed

Research Article

The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study

  • Sivananthaperumal Shanmugasundararaj,

    Affiliation Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Simon Lehle,

    Current address: Interfaculty Institute of Biochemistry, Department of Molecular Medicine, Eberhard Karls University Tübingen, Tübingen, Germany

    Affiliation Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Herve I. Yamodo,

    Affiliation Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • S. Shaukat Husain,

    Affiliation Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Claire Tseng,

    Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Khanh Nguyen,

    Affiliation Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • George H. Addona,

    Current address: Department of In-vitro Pharmacology, Merck Research Labs, West Point, Pennsylvania, United States of America

    Affiliations Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Keith W. Miller

    k_miller@helix.mgh.harvard.edu

    Affiliations Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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