Pre-Existing Isoniazid Resistance, but Not the Genotype of Mycobacterium Tuberculosis Drives Rifampicin Resistance Codon Preference in Vitro

• Indra Bergval ,

  * E-mail: i.bergval@kit.nl

  Affiliation KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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• Brian Kwok,

  Current address: (BK) Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

  Affiliation KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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• Anja Schuitema,

  Affiliation KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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• Kristin Kremer,

  Current address: (KK) Tuberculosis and M/XDR-TB Programme, Division of Communicable Diseases, Health Security and Environment, World Health Organization, Regional Office for Europe, Copenhagen, Denmark

  Affiliation Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

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• Dick van Soolingen,

  Affiliations Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, Departments of Microbiology and of Pulmonary Diseases, Radboud University Nijmegen Medical Centre/University Lung Centre Dekkerswald, Nijmegen, The Netherlands

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• Paul Klatser,

  Affiliation KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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• Richard Anthony

  Affiliation KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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