Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

Xiongwei Cai; Justin J. Gaudet; James K. Mangan; Michael J. Chen; Maria Elena De Obaldia; Zaw Oo; Patricia Ernst; Nancy A. Speck

doi:10.1371/journal.pone.0028430

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Open Access

Peer-reviewed

Research Article

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

Xiongwei Cai ,

Contributed equally to this work with: Xiongwei Cai, Justin J. Gaudet

Affiliation Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Justin J. Gaudet ,

Contributed equally to this work with: Xiongwei Cai, Justin J. Gaudet

Affiliation Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, United States of America
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James K. Mangan,

Affiliation Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Michael J. Chen,

Affiliation Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Maria Elena De Obaldia,

Affiliation Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Zaw Oo,

Affiliation Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Patricia Ernst ,

* E-mail: patricia.ernst@dartmouth.edu (PE); nancyas@exchange.upenn.edu (NAS)

Affiliation Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, United States of America
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Nancy A. Speck

* E-mail: patricia.ernst@dartmouth.edu (PE); nancyas@exchange.upenn.edu (NAS)

Affiliation Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

Xiongwei Cai,
Justin J. Gaudet,
James K. Mangan,
Michael J. Chen,
Maria Elena De Obaldia,
Zaw Oo,
Patricia Ernst,
Nancy A. Speck

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Published: December 1, 2011
https://doi.org/10.1371/journal.pone.0028430

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Bone marrow cells
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Bone marrow transplantation
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Hematopoietic stem cells
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Cell cycle and cell division
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Frameshift mutation
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Gene expression
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Leukemia
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