Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia

• Tanya Hartney ,

  Contributed equally to this work with: Tanya Hartney, Rahul Birari

  Affiliation Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America

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• Rahul Birari ,

  Contributed equally to this work with: Tanya Hartney, Rahul Birari

  Affiliation Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America

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• Sujatha Venkataraman,

  Affiliation Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America

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• Leah Villegas,

  Affiliations Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America, Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora, Colorado, United States of America

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• Maylyn Martinez,

  Affiliation Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America

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• Stephen M. Black,

  Affiliation Georgia Health Sciences University, Augusta, Georgia, United States of America

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• Kurt R. Stenmark,

  Affiliations Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America, Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora, Colorado, United States of America

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• Eva Nozik-Grayck

  * E-mail: Eva.Grayck@ucdenver.edu

  Affiliations Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America, Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora, Colorado, United States of America

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