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Open Access

Peer-reviewed

Research Article

Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

  • Ahmed E. Enayetallah ,

    Ahmed.Enayetallah@pfizer.com

    Affiliation Compound Safety Prediction Group, Pfizer Inc., Groton, Connecticut, United States of America

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  • Daniel Ziemek,

    Affiliation Computational Sciences Center of Emphasis, Pfizer Inc., Cambridge, Massachusetts, United States of America

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  • Michael T. Leininger,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Ranjit Randhawa,

    Affiliation Computational Sciences Center of Emphasis, Pfizer Inc., Cambridge, Massachusetts, United States of America

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  • Jianxin Yang,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Tara B. Manion,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Dawn E. Mather,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • William J. Zavadoski,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Max Kuhn,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Judith L. Treadway,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Shelly Ann G. des Etages,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • E. Michael Gibbs,

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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  • Nigel Greene,

    Affiliation Compound Safety Prediction Group, Pfizer Inc., Groton, Connecticut, United States of America

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  • Claire M. Steppan

    Affiliation Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Inc., Groton, Connecticut, United States of America

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