Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [64Cu]-ATSM, [99mTc]-HL91 and [18F]-FMISO Tumor Hypoxia Accumulation

Veerle Kersemans; Bart Cornelissen; Rebekka Hueting; Matthew Tredwell; Kamila Hussien; Philip D. Allen; Nadia Falzone; Sally A. Hill; Jonathan R. Dilworth; Veronique Gouverneur; Ruth J. Muschel; Sean C. Smart

doi:10.1371/journal.pone.0025911

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Open Access

Peer-reviewed

Research Article

Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [⁶⁴Cu]-ATSM, [^99mTc]-HL91 and [¹⁸F]-FMISO Tumor Hypoxia Accumulation

Veerle Kersemans ,

* E-mail: Veerle.Kersemans@oncology.ox.ac.uk

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Bart Cornelissen,

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Rebekka Hueting,

Affiliation Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom
⨯
Matthew Tredwell,

Affiliation Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom
⨯
Kamila Hussien,

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Philip D. Allen,

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Nadia Falzone,

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Sally A. Hill,

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Jonathan R. Dilworth,

Affiliation Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom
⨯
Veronique Gouverneur,

Affiliation Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom
⨯
Ruth J. Muschel,

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯
Sean C. Smart

Affiliation Cancer Research United Kingdom/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
⨯

Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [⁶⁴Cu]-ATSM, [^99mTc]-HL91 and [¹⁸F]-FMISO Tumor Hypoxia Accumulation

Veerle Kersemans,
Bart Cornelissen,
Rebekka Hueting,
Matthew Tredwell,
Kamila Hussien,
Philip D. Allen,
Nadia Falzone,
Sally A. Hill,
Jonathan R. Dilworth,
Veronique Gouverneur

x

Published: November 15, 2011
https://doi.org/10.1371/journal.pone.0025911

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Cancers and neoplasms
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Oxygen
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Anesthesia
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Positron emission tomography
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