Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

Christopher S. Poultney; Glenn L. Butterfoss; Michelle R. Gutwein; Kevin Drew; David Gresham; Kristin C. Gunsalus; Dennis E. Shasha; Richard Bonneau

doi:10.1371/journal.pone.0023947

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Peer-reviewed

Research Article

Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

Christopher S. Poultney,

Affiliation Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
⨯
Glenn L. Butterfoss,

Affiliation Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
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Michelle R. Gutwein,

Affiliation Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
⨯
Kevin Drew,

Affiliation Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
⨯
David Gresham,

Affiliation Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
⨯
Kristin C. Gunsalus,

Affiliation Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
⨯
Dennis E. Shasha,

Affiliations Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America
⨯
Richard Bonneau

* E-mail: bonneau@nyu.edu

Affiliations Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America
⨯

Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

Christopher S. Poultney,
Glenn L. Butterfoss,
Michelle R. Gutwein,
Kevin Drew,
David Gresham,
Kristin C. Gunsalus,
Dennis E. Shasha,
Richard Bonneau

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Published: September 2, 2011
https://doi.org/10.1371/journal.pone.0023947

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Protein structure
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Protein structure prediction
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Substitution mutation
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Protein sequencing
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Support vector machines
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Mutation databases
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Protein structure comparison
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Kernel functions
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