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Open Access

Peer-reviewed

Research Article

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

  • Chun Hei Antonio Cheung,

    Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan R.O.C.

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  • Wen-Hsing Lin,

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • John Tsu-An Hsu,

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • Tzyh-Chyuan Hour,

    Affiliation Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan R.O.C.

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  • Teng-Kuang Yeh,

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • Shengkai Ko,

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • Tzu-Wen Lien,

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • Mohane Selvaraj Coumar,

    Affiliation Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry, India

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  • Jin-Fen Liu,

    Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan R.O.C.

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  • Wen-Yang Lai,

    Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan R.O.C.

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  • Hui-Yi Shiao,

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • Tian-Ren Lee,

    Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan R.O.C.

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  • Hsing-Pang Hsieh ,

    jychang@nhri.org.tw (JYC); hphsieh@nhri.org.tw (HPH)

    Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan R.O.C.

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  • Jang-Yang Chang

    jychang@nhri.org.tw (JYC); hphsieh@nhri.org.tw (HPH)

    Affiliations National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan R.O.C., Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan R.O.C.

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