Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in European-Descent Populations

• Ana M. Valdes ,

  * E-mail: ana.valdes@kcl.ac.uk

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Unnur Styrkarsdottir,

  Affiliation deCODE Genetics, Reykjavik, Iceland

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• Michael Doherty,

  Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom

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• David L. Morris,

  Affiliation Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, London, United Kingdom

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• Massimo Mangino,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Agu Tamm,

  Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia

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• Sally A. Doherty,

  Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom

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• Kalle Kisand,

  Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia

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• Irina Kerna,

  Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia

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• Ann Tamm,

  Affiliations Department of Internal Medicine, University of Tartu, Tartu, Estonia, Department of Sports Medicine and Rehabilitation, University of Tartu, Tartu, Estonia

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• Margaret Wheeler,

  Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom

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• Rose A. Maciewicz,

  Affiliation Respiratory & Inflammation Research Area, AstraZeneca, Loughborough, United Kingdom

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• Weiya Zhang,

  Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom

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• Kenneth R. Muir,

  Affiliation Health Sciences Research Institute, Warwick Medical School University of Warwick, Coventry, United Kingdom

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• Elaine M. Dennison,

  Affiliation Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom

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• Deborah J. Hart,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Sarah Metrustry,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Ingileif Jonsdottir,

  Affiliations deCODE Genetics, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Gudbjorn F. Jonsson,

  Affiliation deCODE Genetics, Reykjavik, Iceland

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• Helgi Jonsson,

  Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland

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• Thorvaldur Ingvarsson,

  Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, University Hospital, Institution of Health Science, University of Akureyri, Akureyri, Iceland

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• Cyrus Cooper,

  Affiliations Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom, Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

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• Timothy J. Vyse,

  Affiliation Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, London, United Kingdom

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• Tim D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Kari Stefansson ,

  Contributed equally to this work with: Kari Stefansson, Nigel K. Arden

  Affiliations deCODE Genetics, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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•  [ ... ],
• Nigel K. Arden

  Contributed equally to this work with: Kari Stefansson, Nigel K. Arden

  Affiliations Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom, Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

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