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Research Article

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1

  • Yi Zhong equal contributor,

    equal contributor Contributed equally to this work with: Yi Zhong, Zheng Wang

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Zheng Wang equal contributor,

    equal contributor Contributed equally to this work with: Yi Zhong, Zheng Wang

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China

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  • Baojin Fu,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Fan Pan,

    Affiliation: Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Shinichi Yachida,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Mousumi Dhara,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Emilia Albesiano,

    Affiliation: Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Li Li,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Opthamology, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China

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  • Yoshiki Naito,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Felip Vilardell,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Hospital Universitari Arnau de Vilanova, Lleida, Spain

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  • Christopher Cummings,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, University of Colorado School of Medicine, Denver, Colorado, United States of America

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  • Paola Martinelli,

    Affiliation: Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

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  • Ang Li,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Raluca Yonescu,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Qingyong Ma,

    Affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China

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  • Constance A. Griffin,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Francisco X. Real,

    Affiliations: Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain

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  • Christine A. Iacobuzio-Donahue mail

    ciacobu@jhmi.edu

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Published: July 19, 2011
  • DOI: 10.1371/journal.pone.0022129

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