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Research Article

Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing

  • Eric Z. Chen,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Rossa W. K. Chiu,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Hao Sun,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Ranjit Akolekar,

    Affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom

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  • K. C. Allen Chan,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Tak Y. Leung,

    Affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Peiyong Jiang,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Yama W. L. Zheng,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Fiona M. F. Lun,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Lisa Y. S. Chan,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Yongjie Jin,

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Attie T. J. I. Go,

    Affiliation: VU University Medical Center, Amsterdam, The Netherlands

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  • Elizabeth T. Lau,

    Affiliation: Tsan Yuk Hospital, Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong SAR, China

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  • William W. K. To,

    Affiliation: United Christian Hospital, Hong Kong SAR, China

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  • Wing C. Leung,

    Affiliation: Kwong Wah Hospital, Hong Kong SAR, China

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  • Rebecca Y. K. Tang,

    Affiliation: Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China

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  • Sidney K. C. Au-Yeung,

    Affiliation: Tuen Mun Hospital, Hong Kong SAR, China

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  • Helena Lam,

    Affiliation: Princess Margaret Hospital, Hospital Authority, Hong Kong SAR, China

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  • Yu Y. Kung,

    Affiliation: YY Kung Medical Centre, Hong Kong SAR, China

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  • Xiuqing Zhang,

    Affiliations: Joint Chinese University of Hong Kong-Beijing Genomics Institute Genome Research Centre, Li Ka Shing Institute of Health Sciences, Hong Kong SAR, China, Beijing Genomics Institute at Shenzhen, Shenzhen, China

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  • John M. G. van Vugt,

    Affiliation: VU University Medical Center, Amsterdam, The Netherlands

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  • Ryoko Minekawa,

    Affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom

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  • Mary H. Y. Tang,

    Affiliation: Tsan Yuk Hospital, Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong SAR, China

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  • Jun Wang,

    Affiliations: Joint Chinese University of Hong Kong-Beijing Genomics Institute Genome Research Centre, Li Ka Shing Institute of Health Sciences, Hong Kong SAR, China, Beijing Genomics Institute at Shenzhen, Shenzhen, China

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  • Cees B. M. Oudejans,

    Affiliation: VU University Medical Center, Amsterdam, The Netherlands

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  • Tze K. Lau,

    Affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China

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  • Kypros H. Nicolaides,

    Affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom

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  • Y. M. Dennis Lo mail

    loym@cuhk.edu.hk

    Affiliations: Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China, Joint Chinese University of Hong Kong-Beijing Genomics Institute Genome Research Centre, Li Ka Shing Institute of Health Sciences, Hong Kong SAR, China

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  • Published: July 06, 2011
  • DOI: 10.1371/journal.pone.0021791

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