Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

• Jihui Ping ,

  Contributed equally to this work with: Jihui Ping, Liya Keleta, Nicole E. Forbes

  Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, University of Ottawa, Ottawa, Ontario, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• Liya Keleta ,

  Contributed equally to this work with: Jihui Ping, Liya Keleta, Nicole E. Forbes

  Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, University of Ottawa, Ottawa, Ontario, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• Nicole E. Forbes ,

  Contributed equally to this work with: Jihui Ping, Liya Keleta, Nicole E. Forbes

  Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, University of Ottawa, Ottawa, Ontario, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• Samar Dankar,

  Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, University of Ottawa, Ottawa, Ontario, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• William Stecho,

  Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, University of Ottawa, Ottawa, Ontario, Canada

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• Shaun Tyler,

  Affiliation National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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• Yan Zhou,

  Affiliations Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• Lorne Babiuk,

  Affiliations Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• Hana Weingartl,

  Affiliations National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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• Rebecca A. Halpin,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Alex Boyne,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Jayati Bera,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Jessicah Hostetler,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Nadia B. Fedorova,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Katie Proudfoot,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Dan A. Katzel,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Tim B. Stockwell,

  Affiliation Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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• Elodie Ghedin,

  Affiliations Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America, Center for Vaccine Research, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• David J. Spiro,

  Affiliations Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America, Viral Genomics Group, J. Craig Venter Institute, Rockville, Maryland, United States of America

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•  [ ... ],
• Earl G. Brown

  * E-mail: Earl.Brown@uottawa.ca

  Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, University of Ottawa, Ottawa, Ontario, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada, Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, Ottawa, Ontario, Canada

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