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Open Access

Peer-reviewed

Research Article

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

  • Samer O. Abdul-Hay,

    Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

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  • Dongcheul Kang,

    Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

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  • Melinda McBride,

    Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

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  • Lilin Li,

    Affiliation Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Ji Zhao,

    Affiliation Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Malcolm A. Leissring

    Leissring@mayo.edu

    Affiliations Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

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