Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome

• Pablo Perez-Martinez ,

  Contributed equally to this work with: Pablo Perez-Martinez, Javier Delgado-Lista

  Affiliation Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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• Javier Delgado-Lista ,

  Contributed equally to this work with: Pablo Perez-Martinez, Javier Delgado-Lista

  Affiliation Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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• Antonio Garcia-Rios,

  Affiliation Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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• Jolene Mc Monagle,

  Affiliation Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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• Hanne L. Gulseth,

  Affiliation Department of Endocrinology, Oslo University Hospital, Oslo, Norway

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• Jose M. Ordovas,

  Affiliations Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America, Department of Epidemiology and Population Genetics, Centro Nacional Investigación Cardiovasculares (CNIC), Madrid, Spain

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• Danielle I. Shaw,

  Affiliation Department of Food and Nutritional Sciences and the Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, Berkshire, United Kingdom

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• Brita Karlström,

  Affiliation Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

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• Beata Kiec-Wilk,

  Affiliation Department of Clinical Biochemistry, and Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland

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• Ellen E. Blaak,

  Affiliation Department of Human Biology, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands

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• Olfa Helal,

  Affiliation INSERM 476, Lipid nutrients and prevention of metabolic diseases, INRA, 1260, Université de la Méditerranée, Marseille, France

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• Małgorzata Malczewska-Malec,

  Affiliation Department of Clinical Biochemistry, and Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland

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• Catherine Defoort,

  Affiliation INSERM 476, Lipid nutrients and prevention of metabolic diseases, INRA, 1260, Université de la Méditerranée, Marseille, France

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• Ulf Risérus,

  Affiliation Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

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• Wim H. M. Saris,

  Affiliation Department of Human Biology, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands

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• Julie A. Lovegrove,

  Affiliation Department of Food and Nutritional Sciences and the Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, Berkshire, United Kingdom

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• Christian A. Drevon,

  Affiliation Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway

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• Helen M. Roche ,

  ¶These authors also contributed equally to this work.

  Affiliation Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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•  [ ... ],
• Jose Lopez-Miranda

  * E-mail: jlopezmir@uco.es

  ¶These authors also contributed equally to this work.

  Affiliation Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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