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Research Article

Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage

  • Rashel V. Grindberg,

    Affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America

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  • Thomas Ishoey,

    Affiliation: J. Craig Venter Institute, San Diego, California, United States of America

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  • Dumitru Brinza,

    Affiliation: Department of Computer Science and Engineering, Center for Algorithmic and Systems Biology, University of California San Diego, La Jolla, California, United States of America

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  • Eduardo Esquenazi,

    Affiliations: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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  • R. Cameron Coates,

    Affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America

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  • Wei-ting Liu,

    Affiliation: Departments of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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  • Lena Gerwick,

    Affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America

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  • Pieter C. Dorrestein,

    Affiliations: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America, Departments of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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  • Pavel Pevzner,

    Affiliation: Department of Computer Science and Engineering, Center for Algorithmic and Systems Biology, University of California San Diego, La Jolla, California, United States of America

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  • Roger Lasken,

    Affiliation: J. Craig Venter Institute, San Diego, California, United States of America

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  • William H. Gerwick mail

    wgerwick@ucsd.edu

    Affiliations: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Published: April 12, 2011
  • DOI: 10.1371/journal.pone.0018565

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