Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

• Åslaug Helland ,

  Contributed equally to this work with: Åslaug Helland, Michael S. Anglesio, Joshy George

  Affiliations Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

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• Michael S. Anglesio ,

  Contributed equally to this work with: Åslaug Helland, Michael S. Anglesio, Joshy George

  Current address: British Columbia Cancer Agency, Vancouver, Canada

  Affiliations Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia, Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

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• Joshy George ,

  Contributed equally to this work with: Åslaug Helland, Michael S. Anglesio, Joshy George

  Affiliations Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia, Department of Biochemistry, University of Melbourne, Parkville, Australia

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• Prue A. Cowin,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Cameron N. Johnstone,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Colin M. House,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Karen E. Sheppard,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Dariush Etemadmoghadam,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Nataliya Melnyk,

  Affiliation British Columbia Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, British Columbia, Canada

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• Anil K. Rustgi,

  Affiliation Department of Medicine and Abramson Cancer Centre, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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• Wayne A. Phillips,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Hilde Johnsen,

  Affiliation Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway

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• Ruth Holm,

  Affiliation Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway

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• Gunnar B. Kristensen,

  Affiliation Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway

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• Michael J. Birrer,

  Affiliation Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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• Australian Ovarian Cancer Study Group,

  Affiliation Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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• Richard B. Pearson,

  Affiliations Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia, Department of Biochemistry, University of Melbourne, Parkville, Australia

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• Anne-Lise Børresen-Dale,

  Affiliations Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

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• David G. Huntsman,

  Affiliations Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada, British Columbia Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, British Columbia, Canada

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• Anna deFazio,

  Affiliations Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia, Westmead Institute for Cancer Research, University of Sydney at the Westmead Millennium Institute, Westmead Hospital, Sydney, New South Wales, Australia

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• Chad J. Creighton,

  Affiliation Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America

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• Gordon K. Smyth,

  Affiliation Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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•  [ ... ],
• David D. L. Bowtell

  * E-mail: d.bowtell@petermac.org

  Affiliations Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia, Department of Biochemistry, University of Melbourne, Parkville, Australia

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