Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s

Mahendra Pratap Kashyap; Abhishek Kumar Singh; Vivek Kumar; Vinay Kumar Tripathi; Ritesh Kumar Srivastava; Megha Agrawal; Vinay Kumar Khanna; Sanjay Yadav; Swatantra Kumar Jain; Aditya Bhushan Pant

doi:10.1371/journal.pone.0017757

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Peer-reviewed

Research Article

Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s

Mahendra Pratap Kashyap,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Abhishek Kumar Singh,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Vivek Kumar,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Vinay Kumar Tripathi,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Ritesh Kumar Srivastava,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Megha Agrawal,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Vinay Kumar Khanna,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Sanjay Yadav,

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯
Swatantra Kumar Jain,

Affiliation Department of Biotechnology, Jamia Hamdard University, New Delhi, India
⨯
Aditya Bhushan Pant

* E-mail: abpant@rediffmail.com

Affiliations Indian Institute of Toxicology Research, Lucknow, India, Council of Scientific and Industrial Research, New Delhi, India
⨯

Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s

Mahendra Pratap Kashyap,
Abhishek Kumar Singh,
Vivek Kumar,
Vinay Kumar Tripathi,
Ritesh Kumar Srivastava,
Megha Agrawal,
Vinay Kumar Khanna,
Sanjay Yadav,
Swatantra Kumar Jain,
Aditya Bhushan Pant

x

Published: March 21, 2011
https://doi.org/10.1371/journal.pone.0017757

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Apoptosis
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Glutathione
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Oxidative stress
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Reactive oxygen species
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Xenobiotic metabolism
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Mitochondria
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Protein expression
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Cell metabolism
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