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Open Access

Peer-reviewed

Research Article

ZIC1 Is Downregulated through Promoter Hypermethylation, and Functions as a Tumor Suppressor Gene in Colorectal Cancer

  • Lihong Gan ,

    Contributed equally to this work with: Lihong Gan, Shujie Chen

    Affiliation Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    ⨯
  • Shujie Chen ,

    Contributed equally to this work with: Lihong Gan, Shujie Chen

    Affiliation Laboratory of Digestive Disease, Clinical Institution of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

    ⨯
  • Jing Zhong,

    Affiliation Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    ⨯
  • Xian Wang,

    Affiliation Key Laboratory of Biotherapy of Zheijang Province, Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    ⨯
  • Emily K. Y. Lam,

    Affiliation Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China

    ⨯
  • Xin Liu,

    Affiliation Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China

    ⨯
  • Jianbin Zhang,

    Affiliation Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China

    ⨯
  • Tianhua Zhou,

    Affiliation Department of Cell Biology and Program in Molecular Cell Biology, School of Medicine Zhejiang University, Hangzhou, China

    ⨯
  • Jun Yu,

    Affiliation Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China

    ⨯
  • Jianmin Si,

    Affiliation Laboratory of Digestive Disease, Clinical Institution of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

    ⨯
  • Liangjing Wang ,

    Wanglj76@hotmail.com

    Affiliation Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    ⨯
  • Hongchuan Jin

    Affiliation Key Laboratory of Biotherapy of Zheijang Province, Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    ⨯

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