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Research Article

Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase

  • Roxana E. Iacob,

    Affiliation: Department of Chemistry & Chemical Biology, and The Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, United States of America

    Current address: Pfizer Inc., Cambridge, Boston, Massachusetts, United States of America

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  • Jianming Zhang,

    Affiliation: Biological Chemistry & Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Nathanael S. Gray,

    Affiliation: Biological Chemistry & Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • John R. Engen mail

    j.engen@neu.edu

    Affiliation: Department of Chemistry & Chemical Biology, and The Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, United States of America

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  • Published: January 10, 2011
  • DOI: 10.1371/journal.pone.0015929

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