The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism

• Chunxing Yang,

  Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Weijia Tan,

  Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Catheryne Whittle,

  Affiliation Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Linghua Qiu,

  Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Lucheng Cao,

  Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Schahram Akbarian,

  Affiliation Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Zuoshang Xu

  * E-mail: Zuoshang.xu@umassmed.edu

  Affiliations Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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