Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells

• Nazanin S. Ruppender,

  Affiliations Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Alyssa R. Merkel,

  Affiliations Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• T. John Martin,

  Affiliations Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Saint Vincent's Institute, Melbourne, Victoria, Australia

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• Gregory R. Mundy †,

  † Deceased.

  Affiliations Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans' Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

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• Julie A. Sterling,

  Affiliations Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans' Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Scott A. Guelcher

  * E-mail: scott.guelcher@vanderbilt.edu

  Affiliations Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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