Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

Michal Mokry; Pantelis Hatzis; Ewart de Bruijn; Jan Koster; Rogier Versteeg; Jurian Schuijers; Marc van de Wetering; Victor Guryev; Hans Clevers; Edwin Cuppen

doi:10.1371/journal.pone.0015092

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Open Access

Peer-reviewed

Research Article

Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

Michal Mokry,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Pantelis Hatzis,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Ewart de Bruijn,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Jan Koster,

Affiliation Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Rogier Versteeg,

Affiliation Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Jurian Schuijers,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Marc van de Wetering,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Victor Guryev,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Hans Clevers,

Affiliation Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Edwin Cuppen

* E-mail: e.cuppen@hubrecht.e

Affiliations Cancer Genomics Center, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
⨯

Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

Michal Mokry,
Pantelis Hatzis,
Ewart de Bruijn,
Jan Koster,
Rogier Versteeg,
Jurian Schuijers,
Marc van de Wetering,
Victor Guryev,
Hans Clevers,
Edwin Cuppen

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Published: November 30, 2010
https://doi.org/10.1371/journal.pone.0015092

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Chromatin
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Immunoprecipitation
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Sequence motif analysis
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Polymerase chain reaction
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Next-generation sequencing
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Binding analysis
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DNA libraries
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Nucleotide sequencing
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