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Open Access

Peer-reviewed

Research Article

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

  • Lavinia Nardinocchi,

    Affiliation Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy

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  • Valentina Pantisano,

    Affiliations Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy, Chair of Endocrinology, Catholic University, Rome, Italy

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  • Rosa Puca,

    Affiliations Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy, Department of Oncology and Experimental Medicine, School of Medicine, University “G. d'Annunzio”, Chieti, Italy

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  • Manuela Porru,

    Affiliation Experimental Chemotherapy, National Cancer Institute “Regina Elena”, Rome, Italy

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  • Aurora Aiello,

    Affiliations Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy, National Research Council, Institute of Neurobiology and Molecular Medicine, Rome, Italy

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  • Annalisa Grasselli,

    Affiliations Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy, National Research Council, Institute of Neurobiology and Molecular Medicine, Rome, Italy

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  • Carlo Leonetti,

    Affiliation Experimental Chemotherapy, National Cancer Institute “Regina Elena”, Rome, Italy

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  • Michal Safran,

    Affiliation Cancer Research Center, Chaim Sheba Medical Center, Tel-Hashomer and Sachler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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  • Gideon Rechavi,

    Affiliation Cancer Research Center, Chaim Sheba Medical Center, Tel-Hashomer and Sachler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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  • David Givol,

    Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

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  • Antonella Farsetti,

    Affiliations Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy, National Research Council, Institute of Neurobiology and Molecular Medicine, Rome, Italy

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  • Gabriella D'Orazi

    gdorazi@unich.it

    Affiliations Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute “Regina Elena”, Rome, Italy, Department of Oncology and Experimental Medicine, School of Medicine, University “G. d'Annunzio”, Chieti, Italy

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