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Research Article

Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

  • Patrick Baum equal contributor,

    equal contributor Contributed equally to this work with: Patrick Baum, Ramona Schmid

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Ramona Schmid equal contributor,

    equal contributor Contributed equally to this work with: Patrick Baum, Ramona Schmid

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Carina Ittrich,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Werner Rust,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Katrin Fundel-Clemens,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Susanne Siewert,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Martin Baur,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Lisa Mara,

    Affiliation: Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

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  • Lore Gruenbaum,

    Affiliation: Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

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  • Armin Heckel,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Roland Eils,

    Affiliation: Institute of Pharmacy and Molecular Biotechnology/BIOQUANT, University of Heidelberg, Heidelberg, Germany

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  • Roland E. Kontermann,

    Affiliation: Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany

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  • Gerald J. Roth,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Florian Gantner,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Andreas Schnapp,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • John E. Park,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Andreas Weith,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Karsten Quast,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Detlev Mennerich mail

    detlev.mennerich@boehringer-ingelheim.com

    Affiliations: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

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  • Published: December 10, 2010
  • DOI: 10.1371/journal.pone.0014272

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