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Research Article

Inactivation of the Ecs ABC Transporter of Staphylococcus aureus Attenuates Virulence by Altering Composition and Function of Bacterial Wall

  • Ing-Marie Jonsson,

    Affiliation: Department of Rheumatology and Inflammation Research, University of Gothenburg, Göteborg, Sweden

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  • Jarmo T. Juuti,

    Affiliation: Antimicrobial Resistance Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland

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  • Patrice François,

    Affiliation: Genomic Research Laboratory, Service of Infectious Diseases, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland

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  • Rana AlMajidi,

    Affiliation: Antimicrobial Resistance Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland

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  • Milla Pietiäinen,

    Affiliation: Antimicrobial Resistance Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland

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  • Myriam Girard,

    Affiliation: Genomic Research Laboratory, Service of Infectious Diseases, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland

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  • Catharina Lindholm,

    Affiliation: Department of Rheumatology and Inflammation Research, University of Gothenburg, Göteborg, Sweden

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  • Manfred J. Saller,

    Affiliation: Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Kluyver Centre for the Genomics of Industrial Fermentations and the Zernike Institute of Advanced Materials, University of Groningen, Haren, The Netherlands

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  • Arnold J. M. Driessen,

    Affiliation: Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Kluyver Centre for the Genomics of Industrial Fermentations and the Zernike Institute of Advanced Materials, University of Groningen, Haren, The Netherlands

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  • Pentti Kuusela,

    Affiliations: Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland, Division of Clinical Microbiology, Helsinki University Central Hospital Laboratory, Helsinki, Finland

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  • Maria Bokarewa,

    Affiliation: Department of Rheumatology and Inflammation Research, University of Gothenburg, Göteborg, Sweden

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  • Jacques Schrenzel,

    Affiliation: Genomic Research Laboratory, Service of Infectious Diseases, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland

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  • Vesa P. Kontinen mail

    vesa.p.kontinen@helsinki.fi

    Affiliations: Antimicrobial Resistance Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland

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  • Published: December 02, 2010
  • DOI: 10.1371/journal.pone.0014209

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