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Research Article

The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine

  • Hayley C. Whitaker mail,

    Hayley.Whitaker@cancer.org.uk

    Affiliation: Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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  • Zsofia Kote-Jarai equal contributor,

    equal contributor Contributed equally to this work with: Zsofia Kote-Jarai, Helen Ross-Adams

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Helen Ross-Adams equal contributor,

    equal contributor Contributed equally to this work with: Zsofia Kote-Jarai, Helen Ross-Adams

    Affiliation: Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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  • Anne Y. Warren,

    Affiliation: Department of Pathology, Addenbrookes Hospital, Cambridge, United Kingdom

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  • Johanna Burge,

    Affiliation: Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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  • Anne George,

    Affiliation: Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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  • Elizabeth Bancroft,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Sameer Jhavar,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Daniel Leongamornlert,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Malgorzata Tymrakiewicz,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Edward Saunders,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Elizabeth Page,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Anita Mitra,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Gillian Mitchell,

    Affiliation: Peter Maccallum Cancer Centre, Victoria, Australia

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  • Geoffrey J. Lindeman,

    Affiliation: The Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • D. Gareth Evans,

    Affiliation: Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

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  • Ignacio Blanco,

    Affiliation: Catalonian Institute of Oncology, L'Hospitalet, Barcelona, Spain

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  • Catherine Mercer,

    Affiliation: Wessex Clinical Genetics Service, The Princess Anne Hospital, Southampton, United Kingdom

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  • Wendy S. Rubinstein,

    Affiliation: NorthShore University Health System, Evanston, Illinois, United States of America

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  • Virginia Clowes,

    Affiliation: Department of Clinical Genetics, Addenbrookes Hospital, Cambridge, United Kingdom

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  • Fiona Douglas,

    Affiliation: Institute of Human Genetics, Newcastle-Upon-Tyne, United Kingdom

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  • Shirley Hodgson,

    Affiliation: St George's, University of London, London, United Kingdom

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  • Lisa Walker,

    Affiliation: Oxford Regional Genetics Centre, Churchill Hospital, Oxford, United Kingdom

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  • Alan Donaldson,

    Affiliation: St Michael's Hospital, Bristol, United Kingdom

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  • Louise Izatt,

    Affiliation: Guy's Hospital, London, United Kingdom

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  • Huw Dorkins,

    Affiliation: Kennedy Galton Centre, Northwick Park Hospital, Harrow, Middlesex, United Kingdom

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  • Alison Male,

    Affiliation: Institute of Child Health, London, United Kingdom

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  • Kathy Tucker,

    Affiliation: Prince of Wales Hospital, Sydney, New South Wales, Australia

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  • Alan Stapleton,

    Affiliation: Repatriation General Hospital, Adelaide, Australia

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  • Jimmy Lam,

    Affiliation: Repatriation General Hospital, Adelaide, Australia

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  • Judy Kirk,

    Affiliation: Familial Cancer Service, Westmead Hospital, Westmead, New South Wales, Australia

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  • Hans Lilja,

    Affiliation: Departments of Clinical Laboratories, Surgery, Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Douglas Easton,

    Affiliation: Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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  • The IMPACT Study Steering Committee,

    List of The IMPACT Study Steering Committee available on request.

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  • The IMPACT Study Collaborators,

    List of The IMPACT Study Collaborators available on request.

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  • UK GPCS Collaborators,

    List of UK GPCS Collaborators available on request.

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  • Colin Cooper,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • Rosalind Eeles,

    Affiliations: The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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  • David E. Neal

    Affiliation: Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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  • Published: October 13, 2010
  • DOI: 10.1371/journal.pone.0013363

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