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Research Article

A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression

  • Jessica A. Hill equal contributor,

    equal contributor Contributed equally to this work with: Jessica A. Hill, Marta Szabat, Corinne A. Hoesli

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Marta Szabat equal contributor,

    equal contributor Contributed equally to this work with: Jessica A. Hill, Marta Szabat, Corinne A. Hoesli

    Affiliation: Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Corinne A. Hoesli equal contributor,

    equal contributor Contributed equally to this work with: Jessica A. Hill, Marta Szabat, Corinne A. Hoesli

    Affiliation: Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Blair K. Gage,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Yu Hsuan C. Yang,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • David E. Williams,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Michael J. Riedel,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Dan S. Luciani,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Tatyana B. Kalynyak,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Kevin Tsai,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Ziliang Ao,

    Affiliation: Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Raymond J. Andersen,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Garth L. Warnock,

    Affiliation: Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • James M. Piret,

    Affiliation: Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Timothy J. Kieffer,

    Affiliations: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • James D. Johnson mail

    jimjohn@interchange.ubc.ca

    Affiliations: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Published: September 23, 2010
  • DOI: 10.1371/journal.pone.0012958

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