Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration

Francis Béby; Michael Housset; Nicolas Fossat; Coralie Le Greneur; Frédéric Flamant; Pierre Godement; Thomas Lamonerie

doi:10.1371/journal.pone.0011673

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Research Article

Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration

Francis Béby,

Affiliation Institut de Génomique Fonctionnelle de Lyon, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Institut National de la Recherche Agronomique, Université de Lyon, Lyon, France
⨯
Michael Housset,

Affiliation Institut de Biologie du Développement et Cancer, Centre National de la Recherche Scientifique, Université de Nice Sophia-Antipolis, Nice, France
⨯
Nicolas Fossat,

Affiliation Embryology Unit, Children's Medical Research Institute, Sydney Medical School, University of Sydney, Wentworthville, Australia
⨯
Coralie Le Greneur,

Affiliations Institut de Génomique Fonctionnelle de Lyon, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Institut National de la Recherche Agronomique, Université de Lyon, Lyon, France, Institut de Biologie du Développement et Cancer, Centre National de la Recherche Scientifique, Université de Nice Sophia-Antipolis, Nice, France
⨯
Frédéric Flamant,

Affiliation Institut de Génomique Fonctionnelle de Lyon, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Institut National de la Recherche Agronomique, Université de Lyon, Lyon, France
⨯
Pierre Godement,

Affiliation Institut de Génomique Fonctionnelle de Lyon, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Institut National de la Recherche Agronomique, Université de Lyon, Lyon, France
⨯
Thomas Lamonerie

* E-mail: lamonerie@unice.fr

Affiliations Institut de Génomique Fonctionnelle de Lyon, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Institut National de la Recherche Agronomique, Université de Lyon, Lyon, France, Institut de Biologie du Développement et Cancer, Centre National de la Recherche Scientifique, Université de Nice Sophia-Antipolis, Nice, France
⨯

Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration

Francis Béby,
Michael Housset,
Nicolas Fossat,
Coralie Le Greneur,
Frédéric Flamant,
Pierre Godement,
Thomas Lamonerie

x

Published: July 21, 2010
https://doi.org/10.1371/journal.pone.0011673

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Photoreceptors
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Retina
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Epithelium
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Pigments
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Apoptosis
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Messenger RNA
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Ganglion cells
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Mouse models
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