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Research Article

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

  • Melissa C. Paoloni,

    Affiliation: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Christina Mazcko,

    Affiliation: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Elizabeth Fox,

    Affiliation: Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Timothy Fan,

    Affiliation: University of Illinois, Urbana, Illinois, United States of America

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  • Susan Lana,

    Affiliation: Colorado State University, Fort Collins, Colorado, United States of America

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  • William Kisseberth,

    Affiliation: Ohio State University, Columbus, Ohio, United States of America

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  • David M. Vail,

    Affiliation: University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Kaylee Nuckolls,

    Affiliation: Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Tanasa Osborne,

    Affiliation: Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Samuel Yalkowsy,

    Affiliation: University of Arizona College of Pharmacy, Tucson, Arizona, United States of America

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  • Daniel Gustafson,

    Affiliation: Colorado State University, Fort Collins, Colorado, United States of America

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  • Yunkai Yu,

    Affiliation: Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Liang Cao,

    Affiliation: Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Chand Khanna mail

    khannac@mail.nih.gov

    Affiliations: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America, Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Published: June 08, 2010
  • DOI: 10.1371/journal.pone.0011013

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