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Open Access

Peer-reviewed

Research Article

Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma

  • Michiro Susa ,

    Contributed equally to this work with: Michiro Susa, Arun K. Iyer

    Affiliations Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Arun K. Iyer ,

    Contributed equally to this work with: Michiro Susa, Arun K. Iyer

    Current address: Department of Radiology & Biomedical Imaging, Center for Molecular & Functional Imaging, University of California San Francisco, San Francisco, California, United States of America

    Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Keinosuke Ryu,

    Affiliations Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    ⨯
  • Edwin Choy,

    Affiliation Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    ⨯
  • Francis J. Hornicek,

    Affiliations Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    ⨯
  • Henry Mankin,

    Affiliation Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Lara Milane,

    Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Mansoor M. Amiji,

    Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Zhenfeng Duan

    zduan@partners.org

    Affiliations Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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