A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

• Nidhi Gupta ,

  Contributed equally to this work with: Nidhi Gupta, Niels Fisker

  Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada

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• Niels Fisker ,

  Contributed equally to this work with: Nidhi Gupta, Niels Fisker

  Affiliation Santaris Pharma A/S, Hørsholm, Denmark

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• Marie-Claude Asselin,

  Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada

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• Marie Lindholm,

  Affiliation Santaris Pharma A/S, Hørsholm, Denmark

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• Christoph Rosenbohm,

  Affiliation Santaris Pharma A/S, Hørsholm, Denmark

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• Henrik Ørum,

  Affiliation Santaris Pharma A/S, Hørsholm, Denmark

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• Joacim Elmén,

  Affiliation Santaris Pharma A/S, Hørsholm, Denmark

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• Nabil G. Seidah ,

  * E-mail: seidahn@ircm.qc.ca

  ¶These authors also contributed equally to this work.

  Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada

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• Ellen Marie Straarup

  ¶These authors also contributed equally to this work.

  Affiliation Santaris Pharma A/S, Hørsholm, Denmark

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