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Research Article

HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission

  • Vladimir Novitsky,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Rui Wang,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Hermann Bussmann,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Shahin Lockman,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Marianna Baum,

    Affiliation: Department of Dietetics and Nutrition, Robert R. Stempel School of Public Health, Florida International University, Miami, Florida, United States of America

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  • Roger Shapiro,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Ibou Thior,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Carolyn Wester,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • C. William Wester,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana, Division of Infectious Diseases, Vanderbilt University School of Medicine, Vanderbilt Institute of Global Health (VIGH), Nashville, Tennessee, United States of America

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  • Anthony Ogwu,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Aida Asmelash,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Rosemary Musonda,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Adriana Campa,

    Affiliation: Department of Dietetics and Nutrition, Robert R. Stempel School of Public Health, Florida International University, Miami, Florida, United States of America

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  • Sikhulile Moyo,

    Affiliation: Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Erik van Widenfelt,

    Affiliation: Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Madisa Mine,

    Affiliation: Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Claire Moffat,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Mompati Mmalane,

    Affiliation: Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Joseph Makhema,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Richard Marlink,

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Peter Gilbert,

    Affiliation: Department of Biostatistics, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • George R. Seage III,

    Affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Victor DeGruttola,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • M. Essex mail

    messex@hsph.harvard.edu

    Affiliations: Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

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  • Published: April 12, 2010
  • DOI: 10.1371/journal.pone.0010148

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