Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages

Weibin Zha; Guang Liang; Jian Xiao; Elaine J. Studer; Phillip B. Hylemon; William M. Pandak, Jr.; Guangji Wang; Xiaokun Li; Huiping Zhou

doi:10.1371/journal.pone.0009069

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Peer-reviewed

Research Article

Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages

Weibin Zha,

Affiliations Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, China Pharmaceutical University, Nanjing, China
⨯
Guang Liang,

Affiliations Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, School of Pharmacy, Wenzhou Medical College, Wenzhou, China
⨯
Jian Xiao,

Affiliations Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, School of Pharmacy, Wenzhou Medical College, Wenzhou, China
⨯
Elaine J. Studer,

Affiliation Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Phillip B. Hylemon,

Affiliation Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
William M. Pandak, Jr.,

Affiliation Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Guangji Wang ,

* E-mail: hzhou@vcu.edu (HZ); wangguangji01@gmail.com (GW)

Affiliation School of Pharmacy, Wenzhou Medical College, Wenzhou, China
⨯
Xiaokun Li,

Affiliation School of Pharmacy, Wenzhou Medical College, Wenzhou, China
⨯
Huiping Zhou

* E-mail: hzhou@vcu.edu (HZ); wangguangji01@gmail.com (GW)

Affiliations Department of Microbiology & Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, School of Pharmacy, Wenzhou Medical College, Wenzhou, China
⨯

Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages

Weibin Zha,
Guang Liang,
Jian Xiao,
Elaine J. Studer,
Phillip B. Hylemon,
William M. Pandak, Jr.,
Guangji Wang,
Xiaokun Li,
Huiping Zhou

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Published: February 9, 2010
https://doi.org/10.1371/journal.pone.0009069

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HIV
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Macrophages
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Inflammation
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ERK signaling cascade
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HIV prevention
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Endoplasmic reticulum stress response
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HIV infections
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Cardiovascular therapy
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