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Research Article

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

  • Yi-Chun Loraine Tung,

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Eduard Ayuso equal contributor,

    equal contributor Contributed equally to this work with: Eduard Ayuso, Xiaoye Shan

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

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  • Xiaoye Shan equal contributor,

    equal contributor Contributed equally to this work with: Eduard Ayuso, Xiaoye Shan

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Fatima Bosch,

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

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  • Stephen O'Rahilly mail,

    so104@medschl.cam.ac.uk (SO); gshy2@cam.ac.uk (GSHY)

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Anthony P. Coll,

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Giles S. H. Yeo mail

    so104@medschl.cam.ac.uk (SO); gshy2@cam.ac.uk (GSHY)

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pone.0008771

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