Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

• Andrea Sartore-Bianchi ,

  Contributed equally to this work with: Andrea Sartore-Bianchi, Federica Di Nicolantonio

  Affiliation The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy

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• Federica Di Nicolantonio ,

  Contributed equally to this work with: Andrea Sartore-Bianchi, Federica Di Nicolantonio

  Affiliation Laboratory of Molecular Genetics, Division of Genetics and Oncogenomics, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Turin, Italy

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• Michele Nichelatti,

  Affiliation Service of Biostatistics, Ospedale Niguarda Ca' Granda, Milan, Italy

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• Francesca Molinari,

  Affiliation Laboratory of Molecular Diagnostic, Istituto Cantonale di Patologia, Locarno, Switzerland

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• Sara De Dosso,

  Affiliation Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland

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• Piercarlo Saletti,

  Affiliation Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland

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• Miriam Martini,

  Affiliation Laboratory of Molecular Genetics, Division of Genetics and Oncogenomics, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Turin, Italy

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• Tiziana Cipani,

  Affiliation The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy

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• Giovanna Marrapese,

  Affiliation The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy

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• Luca Mazzucchelli,

  Affiliation Laboratory of Molecular Diagnostic, Istituto Cantonale di Patologia, Locarno, Switzerland

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• Simona Lamba,

  Affiliation Laboratory of Molecular Genetics, Division of Genetics and Oncogenomics, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Turin, Italy

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• Silvio Veronese,

  Affiliation Division of Pathology, Ospedale Niguarda Ca' Granda, Milan, Italy

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• Milo Frattini,

  Affiliation Laboratory of Molecular Diagnostic, Istituto Cantonale di Patologia, Locarno, Switzerland

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• Alberto Bardelli ,

  * E-mail: salvatore.siena@ospedaleniguarda.it (SS); a.bardelli@unito.it (AB)

  ¶These authors also contributed equally to this work.

  Affiliations Laboratory of Molecular Genetics, Division of Genetics and Oncogenomics, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Turin, Italy, FIRC Institute of Molecular Oncology, Milan, Italy

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• Salvatore Siena

  * E-mail: salvatore.siena@ospedaleniguarda.it (SS); a.bardelli@unito.it (AB)

  ¶These authors also contributed equally to this work.

  Affiliation The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy

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