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Research Article

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

  • Patrice Dubreuil mail,

    patrice.dubreuil@inserm.fr (PD); olivier.hermine@nck.aphp.fr (OH)

    Affiliations: INSERM, U891, Centre de Recherche en Cancérologie de Marseille, Signalisation, Hematopoiesis and Mechanisms of Oncogenesis, Centre de référence des mastocytoses, Marseille, France, Institut Paoli-Calmettes, Marseille, France, Univ Méditerranée, Marseille, France, AB Science SA, Paris, France

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  • Sébastien Letard,

    Affiliations: INSERM, U891, Centre de Recherche en Cancérologie de Marseille, Signalisation, Hematopoiesis and Mechanisms of Oncogenesis, Centre de référence des mastocytoses, Marseille, France, Institut Paoli-Calmettes, Marseille, France, Univ Méditerranée, Marseille, France, AB Science SA, Paris, France

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  • Marco Ciufolini,

    Affiliations: AB Science SA, Paris, France, University of British Columbia, Department of Chemistry, Vancouver, British Columbia, Canada

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  • Laurent Gros,

    Affiliation: AB Science SA, Paris, France

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  • Martine Humbert,

    Affiliation: AB Science SA, Paris, France

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  • Nathalie Castéran,

    Affiliation: AB Science SA, Paris, France

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  • Laurence Borge,

    Affiliations: INSERM, U891, Centre de Recherche en Cancérologie de Marseille, Signalisation, Hematopoiesis and Mechanisms of Oncogenesis, Centre de référence des mastocytoses, Marseille, France, Institut Paoli-Calmettes, Marseille, France, Univ Méditerranée, Marseille, France

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  • Bérengère Hajem,

    Affiliation: AB Science SA, Paris, France

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  • Anne Lermet,

    Affiliation: AB Science SA, Paris, France

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  • Wolfgang Sippl,

    Affiliation: Institute of Pharmaceutical Chemistry, Martin-Luther-Universität, Halle, Wittenberg, Germany

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  • Edwige Voisset,

    Affiliations: INSERM, U891, Centre de Recherche en Cancérologie de Marseille, Signalisation, Hematopoiesis and Mechanisms of Oncogenesis, Centre de référence des mastocytoses, Marseille, France, Institut Paoli-Calmettes, Marseille, France, Univ Méditerranée, Marseille, France

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  • Michel Arock,

    Affiliation: Laboratory of Oncology and Molecular Pharmacology, CNRS, UMR 8113, Ecole Normale Supérieure de Cachan, Cachan, France

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  • Christian Auclair,

    Affiliations: AB Science SA, Paris, France, Laboratory of Oncology and Molecular Pharmacology, CNRS, UMR 8113, Ecole Normale Supérieure de Cachan, Cachan, France

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  • Phillip S. Leventhal,

    Affiliation: AB Science SA, Paris, France

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  • Colin D. Mansfield,

    Affiliation: AB Science SA, Paris, France

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  • Alain Moussy,

    Affiliation: AB Science SA, Paris, France

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  • Olivier Hermine mail

    patrice.dubreuil@inserm.fr (PD); olivier.hermine@nck.aphp.fr (OH)

    Affiliations: AB Science SA, Paris, France, Service d'Hematologie, CNRS, UMR 8147, Centre de référence des mastocytoses, Université Paris V René Descartes, Hôpital Necker, Paris, France

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  • Published: September 30, 2009
  • DOI: 10.1371/journal.pone.0007258

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