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Open Access

Peer-reviewed

Research Article

Design of RNAi Hairpins for Mutation-Specific Silencing of Ataxin-7 and Correction of a SCA7 Phenotype

  • Janine Scholefield,

    Affiliations Division of Human Genetics/MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • L. Jacquie Greenberg,

    Affiliation Division of Human Genetics/MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Marc S. Weinberg,

    Affiliation Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa

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  • Patrick B. Arbuthnot,

    Affiliation Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa

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  • Amr Abdelgany,

    Affiliation Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Matthew J. A. Wood

    matthew.wood@dpag.ox.ac.uk

    Affiliation Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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