New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors

Laurent Mamelli; Sylvain Petit; Jacqueline Chevalier; Carmela Giglione; Aurélie Lieutaud; Thierry Meinnel; Isabelle Artaud; Jean-Marie Pagès

doi:10.1371/journal.pone.0006443

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Peer-reviewed

Research Article

New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors

Laurent Mamelli,

Affiliation UMR-MD1, Transporteurs Membranaires, Chimiorésistance et Drug-Design, Facultés de Médecine et de Pharmacie, IFR 88, Université de la Méditerranée, Marseille, France
⨯
Sylvain Petit,

Affiliations UMR8601-CNRS, Université Paris Descartes, Laboratoire de Chimie et Biochimie, Pharmacologiques et Toxicologiques, Paris, France, UPR2355-CNRS, Institut des Sciences du Végétal, Centre National de Recherche Scientifique, Gif sur Yvette, France
⨯
Jacqueline Chevalier,

Affiliation UMR-MD1, Transporteurs Membranaires, Chimiorésistance et Drug-Design, Facultés de Médecine et de Pharmacie, IFR 88, Université de la Méditerranée, Marseille, France
⨯
Carmela Giglione,

Affiliation UPR2355-CNRS, Institut des Sciences du Végétal, Centre National de Recherche Scientifique, Gif sur Yvette, France
⨯
Aurélie Lieutaud,

Affiliation UMR-MD1, Transporteurs Membranaires, Chimiorésistance et Drug-Design, Facultés de Médecine et de Pharmacie, IFR 88, Université de la Méditerranée, Marseille, France
⨯
Thierry Meinnel,

Affiliation UPR2355-CNRS, Institut des Sciences du Végétal, Centre National de Recherche Scientifique, Gif sur Yvette, France
⨯
Isabelle Artaud,

Affiliation UMR8601-CNRS, Université Paris Descartes, Laboratoire de Chimie et Biochimie, Pharmacologiques et Toxicologiques, Paris, France
⨯
Jean-Marie Pagès

* E-mail: Jean-Marie.PAGES@univmed.fr

Affiliation UMR-MD1, Transporteurs Membranaires, Chimiorésistance et Drug-Design, Facultés de Médecine et de Pharmacie, IFR 88, Université de la Méditerranée, Marseille, France
⨯

New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors

Laurent Mamelli,
Sylvain Petit,
Jacqueline Chevalier,
Carmela Giglione,
Aurélie Lieutaud,
Thierry Meinnel,
Isabelle Artaud,
Jean-Marie Pagès

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Published: July 30, 2009
https://doi.org/10.1371/journal.pone.0006443

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Antibiotics
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Antibacterials
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Antibiotic resistance
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Gram negative bacteria
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Pseudomonas aeruginosa
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Polymyxins
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Permeability
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Bacterial pathogens
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