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Research Article

Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria: A Prospective Multi-Centre Individual Patient Data Analysis

  • Julien Zwang,

    Affiliation: Shoklo Malaria Research Unit, Mae Sot, Thailand

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  • Elizabeth A. Ashley,

    Affiliation: Shoklo Malaria Research Unit, Mae Sot, Thailand

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  • Corine Karema,

    Affiliations: National Malaria Control Programme, Kigali, Rwanda, Institute of Tropical Medicine, Antwerp, Belgium

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  • Umberto D'Alessandro,

    Affiliation: Institute of Tropical Medicine, Antwerp, Belgium

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  • Frank Smithuis,

    Affiliation: Médecins Sans Frontières - Holland, Yangon, Myanmar

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  • Grant Dorsey,

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Bart Janssens,

    Affiliation: Médecins Sans Frontières- Belgium, Phnom Penh, Cambodia

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  • Mayfong Mayxay,

    Affiliations: Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, Oxford, United Kingdom, Wellcome Trust – Mahosot Hospital – Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos, Department of Postgraduate Studies and Research, University of Health Sciences, Vientiane, Laos

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  • Paul Newton,

    Affiliation: Wellcome Trust – Mahosot Hospital – Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos

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  • Pratap Singhasivanon,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Kasia Stepniewska,

    Affiliations: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, Oxford, United Kingdom

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  • Nicholas J. White,

    Affiliations: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, Oxford, United Kingdom

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  • François Nosten mail

    SMRU@tropmedres.ac

    Affiliations: Shoklo Malaria Research Unit, Mae Sot, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, Oxford, United Kingdom

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  • Published: July 29, 2009
  • DOI: 10.1371/journal.pone.0006358

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