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Research Article

Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects

  • Xue-Qin Chen,

    Affiliation: State Key laboratory of Drug Research, Department of Pharmacology II, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Jing Zhang,

    Affiliation: Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • John L. Neumeyer,

    Affiliation: Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America

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  • Guo-Zhang Jin,

    Affiliation: State Key laboratory of Drug Research, Department of Pharmacology II, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Guo-Yuan Hu,

    Affiliation: State Key laboratory of Drug Research, Department of Pharmacology II, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Ao Zhang mail,

    aozhang@mail.shcnc.ac.cn (AZ); xczhen@mail.shcnc.ac.cn (XZ)

    Affiliation: Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Xuechu Zhen mail

    aozhang@mail.shcnc.ac.cn (AZ); xczhen@mail.shcnc.ac.cn (XZ)

    Affiliation: State Key laboratory of Drug Research, Department of Pharmacology II, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Published: June 05, 2009
  • DOI: 10.1371/journal.pone.0005811

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