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Open Access

Peer-reviewed

Research Article

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

  • Erik Kvam,

    Affiliations Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America

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  • Brent L. Nannenga,

    Affiliation Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Min S. Wang,

    Affiliation Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Zongjian Jia,

    Affiliation Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Michael R. Sierks,

    Affiliation Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Anne Messer

    messer@wadsworth.org

    Affiliations Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America

    ⨯

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