Structural Basis and Catalytic Mechanism for the Dual Functional Endo-β-N-Acetylglucosaminidase A

• Jie Yin ,

  Contributed equally to this work with: Jie Yin, Lei Li

  Affiliations National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Graduate School of the Chinese Academy of Sciences, Beijing, China

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• Lei Li ,

  Contributed equally to this work with: Jie Yin, Lei Li

  Affiliations National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Shandong, China, Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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• Neil Shaw,

  Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Yang Li,

  Affiliations National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Graduate School of the Chinese Academy of Sciences, Beijing, China

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• Jing Katherine Song,

  Affiliation Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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• Wenpeng Zhang,

  Affiliation Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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• Chengfeng Xia,

  Affiliation Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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• Rongguang Zhang,

  Affiliation Structural Biology Center, Advanced Photon Source, Argonne National Laboratory, Illinois, United States of America

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• Andrzej Joachimiak,

  Affiliation Structural Biology Center, Advanced Photon Source, Argonne National Laboratory, Illinois, United States of America

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• Hou-Cheng Zhang,

  Affiliation National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Shandong, China

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• Lai-Xi Wang,

  Affiliation Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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• Zhi-Jie Liu ,

  * E-mail: zjliu@ibp.ac.cn (Z-JL); pwang@sdu.edu.cn (PW)

  Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Peng Wang

  * E-mail: zjliu@ibp.ac.cn (Z-JL); pwang@sdu.edu.cn (PW)

  Affiliations National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Shandong, China, Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy and The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

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