PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

• Wencheng Liu ,

  Contributed equally to this work with: Wencheng Liu, Cristofol Vives-Bauza

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Cristofol Vives-Bauza ,

  Contributed equally to this work with: Wencheng Liu, Cristofol Vives-Bauza

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Rebeca Acín-Peréz-,

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Ai Yamamoto,

  Affiliation Judith P. Sulzberger M.D. Columbia Genome Center and Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, United States of America

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• Yingcai Tan,

  Affiliation Department of Physiology, Weill Medical College of Cornell University, New York, New York, United States of America

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• Yanping Li,

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Jordi Magrané,

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Mihaela A. Stavarache,

  Affiliation Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York, United States of America

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• Sebastian Shaffer,

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Simon Chang,

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Michael G. Kaplitt,

  Affiliation Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York, United States of America

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• Xin-Yun Huang,

  Affiliation Department of Physiology, Weill Medical College of Cornell University, New York, New York, United States of America

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• M. Flint Beal,

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Giovanni Manfredi ,

  * E-mail: gim2004@mail.med.cornell.edu (GM); chl2011@med.cornell.edu (CL)

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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• Chenjian Li

  * E-mail: gim2004@mail.med.cornell.edu (GM); chl2011@med.cornell.edu (CL)

  Affiliation Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, United States of America

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