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Open Access

Peer-reviewed

Research Article

Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines

  • Jeet Gandhi ,

    Contributed equally to this work with: Jeet Gandhi, Jianling Zhang

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Jianling Zhang ,

    Contributed equally to this work with: Jeet Gandhi, Jianling Zhang

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Yang Xie,

    Affiliation Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Junichi Soh,

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Hisayuki Shigematsu,

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Wei Zhang,

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Hiromasa Yamamoto,

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Michael Peyton,

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Luc Girard,

    Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • William W. Lockwood,

    Affiliation Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Wan L. Lam,

    Affiliation Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Marileila Varella-Garcia,

    Affiliation Department of Internal Medicine, University of Colorado Cancer Center, Aurora, Colorado, United States of America

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  • John D. Minna,

    Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Adi F. Gazdar

    adi.gazdar@utsouthwestern.edu

    Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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